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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Mrs. May’s government proposed a rule that would publicly shame employers who hired foreign workers. And her first major speech was full of barbs directed against multiculturalism, including a jab against people who claimed to be “citizens of the world,” whom she called “citizens of nowhere.”
上海软科教育信息咨询有限公司于上周三发布的2018年“世界大学学术排名”显示,中国有62所研究型大学入围这份全球500强高校榜单。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 广州番禺经济技术开发区正式设立
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

新加坡樟宜国际机场已经连续五年在每年一度的Skytrax世界机场大奖评选中获得世界最佳机场。
在电影《007:大破天幕杀机》中饰演邦女郎的贝纳尼丝·玛尔洛(Berenice Marlohe),已经确认加盟导演特伦斯·马立克(TerrenceMalick)执导的最新电影作品,目前此影片正在奥斯汀进行拍摄。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

1.Shailene Woodley

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

这间增加的厨房大约40英尺长(约12米),风格与原建筑保持一致,内有复杂的天花板木制结构和几处由世纪工作室(Century Studios)设计的彩色玻璃板,该工作室是明尼阿波利斯市的一家公司,其玻璃确保来自弗兰克·劳埃德·赖特(Frank Lloyd Wright)曾指定的那家芝加哥制造商。厨房里的不锈钢电器包括一台五英尺宽(约1.5米)的炉灶和一台Sub-zero的冰箱。餐厅区经由10英尺高(约3米)的玻璃门通往屋后的一处露台。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

vt. 把 ...
As well as dancing, she has her eye on singing and acting - she has already acted in the TV shows Drop Dead Diva and Austin & Ally.
《楚乔传》改编自网络小说《11处特工皇妃》,讲述了女奴楚乔的奇遇以及她和燕洵世子的爱情故事。
在人类的历史上,我们正处于最和平的年代。早在二十世纪四十年代,每10万个人中就有300人直接死于战争。我们可以很欣慰地告诉你今天这个数字少于1。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

如果你在寻找一个免费的客户关系管理系统,Zoho或许正适合你。为什么呢?因为它提供了集成的可能性。比如只需添加你的API密钥,就可以轻松与JotForm和Unbounce集成。这意味着只需要几秒钟的时间,销售线索就可以自动发送到你的CRM系统。对于一款免费软件来说,这已经非常强大了。
The best bosses understand the art of delegation. My commenter said something along the lines of, “They’ve fired themselves from their previous job,” meaning that they don’t interfere in the day-to-day and minute-to-minute workflow or processes. In essence, learning to delegate instead of micromanage is about trust。
After weeks of rumors, Phil Jackson failed to move Carmelo Anthony and Derrick Rose, two players who absolutely should have been traded for the long-term benefit of the franchise.
即使我们把吉布森视作租赁合同并且他将在夏天离开,雷霆对这笔交易依然感觉良好。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

China's consumer price inflation decelerated to just 1.3 per cent year-on-year last month, the slowest rate since May. On a month-to-month basis inflation fell by 0.3 per cent, the first negative reading since May.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

科学家们让夫妻进入实验室,在他们开始“别扭”对话时观察他们的压力水平。研究发现,面对压力时,用大笑等积极情绪缓解压力的夫妻在一起的时间往往更久。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

《ScreamRide》
Australian and Spanish schools are doing well, however. Each country’s three representatives have risen up the ranking. Sydney’s Macquarie Graduate School of Management is Australia’s top placed institution at 49 and Spain’s IE Business School moved up four places to eighth, the first time since 2012 that the Madrid school is back in the top 10.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

剧中,罗根的爪子不再迅疾,自愈能力渐失,但他坚持照顾人生导师X教授(X教授的演技让你忍不住为他鼓掌!),看着影片里X教授忍受癫痫的痛苦实在是令人不忍。毫无疑问,该片赚足了粉丝的泪水。如果杰克曼和斯图尔特是认真的,这部片子是他们为对方献上的终篇,这番告别可谓是一曲千古绝唱。
尤吉利时机恰当和思虑周密的举动应该能扭转猛龙下滑的颓势。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 家居建材市场旺季遇冷
Open Access Review Article

Diagnostic technologies for COVID-19: a review

普华永道表示:“我们目前正在调查如何能发生这样的事,并对发生此事深感遗憾。被提名人、电影艺术与科学学院(the Academy)、美国广播公司(ABC)、以及吉米?基梅尔对这一情况处置得体,我们表示感谢。”
When Dickens wrote about the French Revolution in A Tale of Two Cities, he did it with nearly a century of hindsight. Here, at the end of December, I don’t enjoy that luxury. As such, some of the trends I’ve written here are likely to remain in force for the foreseeable future, while others may have already begun to fade. As one of this period’s “noisiest authorities,” I insist only on your receiving this review with just one caveat in mind: Past performance does not guarantee future results.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

As for the molecular motors, they’re geared up to bring huge potential to the fields of medicine and energy.
Washington's twin-obsessions in election year 2010 will be to create jobs and cut the deficit. Little will be accomplished on either count.
单词channel 联想记忆:
n. 学会,学院,协会

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

过去一年中,亚利桑那州最大的赢家是建筑和休闲/酒店行业,这两个行业共增加了超过1万个就业机会。其他快速增长的行业包括商业服务、金融活动、教育和医疗服务。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

This is the 16th edition of the FT global executive MBA ranking.
The finest romance and the most acute anti-romance of the year, from some of the most rigorous intellects in American movies. The relationship between them is perhaps best summed up in this poem by William Blake, called “The Clod and the Pebble”:

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

10月份,中国社会消费品零售总额增长放缓。另一方面,尽管上月出口走弱,中国规模以上工业增加值和全国固定资产投资增长仍大致保持平稳。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

vt. 记载,(用文件

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 三四线城市个贷增长明显
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

A. O. Scott
伊莎贝拉卡敏斯卡(Izabella Kaminska)
Companies are always looking to save money, and outsourcing some roles to freelancers can help. Virtual assistants can perform many of the duties of full-time staffers, but with less commitment. These workers could help expand a business, or just encourage things to run more smoothly.
北弗罗里达大学的一个有趣的实验证明光脚跑步比穿鞋跑步更能提高记忆力。和那些在实验室和室内坐在桌子边进行的试验不同,在这个实验中,研究人员们引入了一些有趣的观点来探索提高记忆力的奥秘。实验的研究对象为“工作记忆”,即人们加工信息和回顾生活细节的能力。科学家们发现,光脚跑步比起穿鞋跑步来说,可以对记忆力产生轻微的提高。在试验中,年龄为18-44周岁的参与者们被要求跑两轮,一次穿鞋,一次不穿鞋。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

我可能会说:“我解雇你是因为你工作不达标。”实际上,我并不会说是因为你实在让人受不了,每次和人沟通都会得罪人。
Grains have fallen about 3 per cent.
The Big Tech backlash will spread to technology industry employees in 2018, as many question whether the work they do really is saving the world.
创始人的心态将为公司定下基调。消极、懒惰和理所应当的心态,不仅浪费时间和金钱,还会损害你的信誉。成功很大程度上取决于能否在犯错后从容地接受批评。直面挑战可以让一位普通的公司老板变成真正的领导者。
值得庆幸的是,这些户籍规定正在发生改变。12月初,在中国中央经济工作会议上,与会代表建议给予农村居民城市户口,这也强有力地证明了户籍制度正在变化。温家宝总理于12月底呼吁,应加快户籍制度改革的进程。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Winners: Mavericks
11月,中国的出口总值增速是预期的2倍多,这增加了中国的贸易顺差。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Recent initiatives to support two-way tourism between the two countries include the trial of the 10-year visitor visa; the open aviation market services arrangement which removes all capacity restrictions for airlines on both sides; and a new Beijing to Sydney service by Qantas Airways which was launched in January.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

I do not see much evidence that radical “managerless” models such as “Holacracy” will catch on. But more companies will realise that if they constantly test innovative ways forward — as start-ups do — they will be more flexible and decisive than old-style bureaucracies and meritocracies.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Economists had forecast a 1.5 per cent annual rate, after a 1.6 per cent reading in September. Beijing's inflation target is "around 3 per cent" this year.
SplashData公司称,在娱乐网站上使用和邮箱及社交网站相同的密码尤其不安全。
在韩国首都首尔,20%年龄介于19到49岁的女性承认她们为了改变样貌,接受过美容整形手术。
Stock pickers encountered difficulty this year in part because of concentration at the top of the market. Just five stocks—Apple, Berkshire Hathaway, Johnson & Johnson, Microsoft, and Intel— accounted for 20% of the market’s gains. If you weren’t at least equally weighted toward them, you had virtually no shot at making up for missing their enormous, index-driving gains. A majority of the market’s stocks did not perform nearly as well. According to the Leuthold Group, only 30% of S&P 1500 stocks posted gains exceeding the index itself. You’d have to go back to 1999 to see anything like this.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

高位且不断上升的美国利率可能很快成为新兴市场危机的驱动因素:此类条件可能导致新兴市场借贷成本升高,还有资本外流以及金融部门冒险意愿下降。
triangle
n. 反映,映像,折射,沉思,影响
The average salary of St Gallen’s alumni jumped to $102,000 three years after graduation compared with $90,000 last year.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

为什么小皇帝詹姆斯不在双头肌和肩膀上再带那些奇怪的饰物,对此我很好奇。当然,我敢打赌他不会再带那些东西——因为它们没啥用处。
The American Film Institute has picked its 10 best movies and TV shows of the year. The titles, presented in alphabetical order, are works AFI's juries have determined advance the art of the moving image, enhance the cultural heritage of America's art form, inspire audiences and artists and make a mark on American society.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

3. Enlisted military personnel
The most popular variation of this line is “Don’t fantasize about big sister: I am only legend.”
5. Will China's migrant workers get permanent urban residence in 2010?
威廉凯特夫妇多次让加拿大人等候多时,例如,抵达加拿大时,两人花了20分钟时间才从飞机上下来接受加方欢迎团队的问候。
The central bank last year spent more than six months signaling its intent to wean the economy off a third round of bond-buying, and the prospect upset markets at just about every turn. Now it's only in the first stage of that process.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

公司:在线票务平台Eventbrite
Among the 18 sectors categorized by the China Securities Regulatory Commission, financial executives ranked the highest with annual pay of 27.36 million yuan, followed by real estate executives at 11.18 million yuan.
vt. 包含,容纳,克制,抑制

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Lady Bird
支持:美国国家评论协会将最佳电影、最佳男主角和最佳女主角奖颁给了这部电影。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 稳投资 有储备有信心
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.
3.The End of the One-Child Policy
7. Viceroy's House

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

自从在2009年从榜单的第一位落到第五位之后,小甜甜布兰妮的排名继续下滑,随着嘎嘎小姐和贾斯汀 比伯这些新星的走红,布兰妮在2010年仅名列第十位。
GoldSeek.com的这个标题发出了红色警报。在评估另外20名专家跟踪的20种周期之后,它总结道:“很多周期表明股市的调整或崩溃已经临近……未雨绸缪是很重要的。在‘窗口’关闭之前,你仍有一些时间!”
Umbrellas for dogs are having a moment. They’re cute and funny, but also practical.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 中国硅藻泥材料协会正式成立
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The fall in profits in December highlights the challenges facing an industrial sector racked by overcapacity and falling prices, adding to pressure on authorities to loosen monetary policy and boost infrastructure spending to cushion the slowdown.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

A Larger Profile

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

BABYLON (Sundance, Thursday) James Nesbitt, recently seen as the obsessed father of a long-vanished child in “The Missing,” shows up here in a very different role: as a calculating old-school police commissioner who hires an American public-relations expert (Brit Marling) to update the image of Scotland Yard. Danny Boyle (“Slumdog Millionaire”) created this satirical drama, which bears some resemblance to Armando Iannucci’s political comedy film “In the Loop.”
sincerely

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 11月广州楼市租赁市场量跌价升
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

当发生问题时,库克会迅速而无情地采取行动。2012年底,苹果过早推出了有缺陷的苹果地图(Apple Maps)应用之后,库克解雇了乔布斯的亲密盟友、领导开发iOS的斯科特?福斯托(Scott Forstall),以及前Dixons首席执行官、掌管苹果零售部门不到一年的约翰?布劳伊特(John Browett)。此举传递出一条信息:库克不会容忍业绩不佳或内部政治。
Take the intriguing reintroduction of “unfeigned regards” — last big in the 18th century and now found on emails from Indian help centres. But the winning sign-off, at the bottom of a message sent one Friday, was: “weekend well”. I nearly awarded it second prize for the best noun pretending to be a verb, though at the last minute this award was snatched by a consultant overheard saying: “Can we cold towel that?”
The raised decoration shows a cartouche — an oval frame around Egyptian hieroglyphics indicating a royal name. Above the frame archaeologists could make out the symbol of an eye and that of a cobra.
In addition, the 1980 stamps were designed by Huang Yongyu, 92, a well-known Chinese master painter, making it a collectible item with extreme value.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Rank: 3
上榜理由:被低估的欧洲瑰宝

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

8.身着平底鞋禁止入场,是吗?
2012年伦敦奥运会室内自行车比赛场馆2012年伦敦奥运会共设26个大项,总计300个小项比赛cupIHumCfz。比赛大项和小项均少于2008年北京奥运会sgK8=M,J)Qa&g9sAp!,。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

But a friend saw a TV report about it and contacted the sorting office. Mr Siddeeq, 74, says he is still eager to read it, despite now being divorced。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

今年的全球女性权势榜中,有9位国家元首,她们治理的国家总GDP达到了11.8万亿美元——其中包括排名第一的权势女性、德国总理安吉拉·默克尔。还有24位公司的首席执行官,她们掌管的公司年营收总计8,930亿美元,另外16位女性创立了自己的公司,包括三位新晋亿万富豪中的两位:托里·伯奇和Spanx公司的萨拉·布雷克里。说起来,今年的榜单上有14位亿万富豪,她们的身家超过了820亿美元。
n. 委员会,委托,委任,佣金,犯罪
For the first time in six years, a new challenger has topped the FT’s ranking of executive MBA programmes.
200911/88510.shtml

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

The paperpot transplanter allows a single person to transplant 264 plants covering over 85ft in just minutes. What used to take hours, now takes minutes. Allowing you to spend less time transplanting crops, and more time doing other things like farm improvements, marketing, sales, or just taking some time off.
陈宇说:“一些互联网行业的天才创造了很多奇迹,但这并不代表一切。每个行业都有各自的规则。在你在这一行业开始之前,你必须要知道如何生产产品,如何销售,如何经营一家公司。我们不能期待一个刚刚毕业的大学生一开始就知道这些经验。”

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

顾名思义,这个真人秀节目还专门拍摄学生们的母亲,展现母亲如何教育孩子与他人竞争。
Emma Morano’s singular achievement in life may have been perseverance. She lived for 117 years, crediting her longevity to raw eggs and her lack of a husband. She died on April 15.
If 2017 was the year of fake news, 2018 is shaping up to be one of fake data. And just as fake news comes in many varieties — real news dubbed by the US president as fake, as well as nonsense gaining huge audiences on social media — so does fake data.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

He argues, however, that “US monetary policy is often just as important as domestic factors in explaining the incidence of EM crises, if not more important.”
犹如船长要驾驶一艘船。如果领导曾不知这个工程或公司如何牵头,公司又怎样知道呢?这不仅仅是关于接下来的步骤或者交付的内容这两点,而更是对部门或公司的未来有一个清楚的认识,他/她能够同公司员工一起交流的内容。
Developer: Supermassive Games, Sony Computer Entertainment

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

“The auction market is extremely selective,” said Henry Pettifer, the head of old master paintings at Christie’s, whose sale total had been dented by a 15th-century Flemish Madonna and child by Hans Memling that the auction house had sold privately for more than 3.5 million and had withdrawn from the sale. “The availability of fresh material is limited,” he added, alluding to how few museum-quality works are in private hands.
截至2016年底,中国仍有4300万农村地区的人口生活在贫困状态下。中国的目标是在2020年时帮助他们脱贫。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

After decades of promise, new gene therapies are starting to deliver real results. Like all new therapies, communicating accurately how and where it works will prove as challenging as the treatment itself.
李说,记者职业排名靠后已经有一段时间了(去年在200个职业中排名第196位)。他说,这次被挤到最后一位很可能是因为有些情况更糟了,如职业前景变差、平均薪资继续下滑、工作时间持续增加等,而且这些因素也让记者的压力更大。
One of the most discussed potential use cases of the block chain is as a decentralized Uber. Instead of using an app, customers could order a car and pay the driver directly, cutting out the middleman. (Sorry, Travis Kalanick.) The block chain can be utilized for everything from the storage of secure documents (that is, a decentralized Dropbox, too) to “watermarking,” in which a specific coin could contain, say, the deed to your house. “The block chain is going to spawn decades of innovation,” says Ryan Selkis, director of investments at the Digital Currency Group, created by former SecondMarket founder Barry Silbert. “It could lead to things like frictionless share issuance, title transfers, smart contracts. Collectively these things make up the backbone of the economy. If you wanted to create a decentralized Uber, Dropbox, Facebook, you could reinvent the Internet.”

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 家居消费贷 你买账吗?
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

《不可思议的杰西卡?詹姆斯》
repertoire

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

The 43-year-old woman was placed on a 12-month good behaviour bond and banned from owning animals.
Company: Eventbrite
不过,一些议员已经开始讨论2月末或因联邦借款上限再度引发僵局。达科称,你永远不能指望决策者们不会搬起石头砸自己的脚。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

PRRI研究总监丹尼尔-考克斯说,一些受访者(包括75%的非白人新教徒)相信恶劣天气既是末日论的证据,也是气候变化的结果。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.
Libby has posted the lyrics on her YouTube channel in the comments section, but here they are for you. There are plenty of lovely English expressions and British English slang that I’ve highlighted in bold for you. Can you guess the meaning? What does “OMG” stand for?

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

联合国下属的国际农业发展基金会(IFAD)上周三表示,2016年,约有2亿名打工人员--其中一半是女性--向他们在亚洲、拉美和非洲的家人汇款4450亿美元。
在数十项小型、以科技为核心的收购中,对Beats Electronics的30亿美元收购成为苹果迄今最大的一笔收购。Beats Electronics是一家有著名音乐人背景的耳机制造商和音乐流媒体服务商。这笔收购仍然让许多苹果分析师感到困惑,但与Beats创始人吉米?艾欧文(Jimmy Iovine)和安德烈?罗米尔?扬(Dr. Dre)合作,让苹果忽略iTunes下载商店数年后,迅速在音乐界重建信誉。如果说库克对错过类似Spotify的音乐订阅服务的快速增长感到愧疚,那么他已迅速弥补了这一点——尽管付出了很高代价。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

[娱乐时尚] Chanel,Now and Then 香奈儿的现在与
Barack Obama went on the offensive over foreign policy in the third and final presidential debate, repeatedly accusing Mitt Romney of flip-flopping on major international issues but failing to deliver a killer blow to his opponent's resurgent campaign.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 4G牌照颁布 智能家居坐上特快列车
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
Mr Koepke argues, however, that the role of US interest rates in provoking EM crises has not been fully understood. He presents evidence that the probability of EM crises is substantially higher during a conjunction of three conditions: during a Fed tightening cycle, when the federal funds rate is above its natural rate (the rate that leads actual output to converge to potential output), and when market participants are surprised by signals that the Fed will tighten policy faster than previously expected.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

出演《美国队长3:英雄决裂》的斯嘉丽-约翰逊排名第三,收入为2500万美元,比去年下降了近30%。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

vt
卢华东表示:“今年是西藏反贫困的重要时期,我们将根据不同情况和引起贫困的原因,继续制定政策和计划,并持续增加资金。”
长话短说,1772年圣诞节后,Seppenwolde很快就破产了。这场灾难是当时荷兰报纸的头条新闻。它彻底毁了阿姆斯特丹一批商人和银行家。为了防止出现全面的信贷崩溃,阿姆斯特丹市只能作为最后贷款人暂时介入。这种情形是不是似曾相识?
有效率的老板必须是有效率的决策者。他或她在每个小的决定上不能有半点犹豫。要能快速精准的做出决定----对以后的结果承担责任(请看第二条)----这是很重要的商业技巧,特别是在管理他人的时候。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Kendall Jenner has knocked Gisele off the top spot as the world's highest paid model for the first time in 15 years.
不过,在财经领域,激烈竞争也是不可避免的。毕业生进入职场后应从基础工作开始,一步步提升综合能力,保持自身竞争力。
这种旅行枕可以随意弯曲变形,您的头怎么放都行。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

但是在对遗骸进行分析后,研究人员发现这些坟墓被重复利用了多次。有些坟墓中包括有10多个的死者,多次的重复埋葬有待于进一步的研究,研究人员写到。
单词yacht 联想记忆:

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Yan Pu, head of portfolio review in Asia at Vanguard, suspects the Asian product mix may be holding things back. For example, Asian providers offer plenty of equity ETFs but very few fixed income products. In the US, she notes, fixed income ETFs are growing rapidly.
单词consciousness 联想记忆:

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

['θ?:tful]

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

下面这条消息,可以给人带来一线希望:市价房的租金太高了,它们明年可能涨不了多少。“好消息是,租金不会再涨了,”米勒说,“坏消息是,它们很可能也不会下降。”
当你需要帮助时,你应该联系你的人脉资源——这正是他们存在的原因。无论你需要他人为你打气,还是想要寻求积累技术经验的建议,你的导师、同事和经理都能为你提供帮助。今天,你可能不知道如何开展某项工作,但你或许足够聪明,能够找到能帮你掌握这种技能的人。一旦你做到这一点,千万不要放松,因为前方总会有其他挑战在等待着你。
肯达尔·詹娜首次击败了15年里世界上收入最高的模特吉赛尔·邦辰。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

announced
The ECB ended the year with a vote on December 3 to cut its deposit rate to minus 0.3 per cent and an expansion in asset purchases that leaves its quantitative easing programme at 1.46tn. The move came days before the US Federal Reserve increased interest rates for the first time since 2006, underlining the sharply divergent policies being pursued on either side of the Atlantic.
商务部本月早些时候表示,消费品的零售销售是去年消费的一项关键指标。该销售额同比增长了10.7%,占去年全国66.4%的GDP增长。
Civil War takes place after the events of Avengers: Age of Ultron, when the government decides that the Avengers should work under them and not on their own. Steve Rogers, aka Captain America, is against this idea whereas Tony Stark, aka Iron Man, is with the government. This leads to a conflict between Captain America and Iron Man.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

There was no immediate word from the Romney camp on the reported results。
变化世界中的得与失

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

高部长称,目前全国商品交易市场已经超过8万家,社会消费品零售总额在年底预计达到30万亿元,而消费对GDP的贡献接近60%。
Ronaldo's monster pay-packet was the result of his eye-watering pound 38.5 million-a-year salary with Spanish giants Real Madrid and endorsement deals with the likes of Nike, watchmaker Tag Heuer and nutrition supplements group Herbalife - themselves worth pound 22 million.
波比的父亲,28岁的安顿,承认他一开始对波比的风格路线有所顾虑,不过现在他已经欣然接受这件事了。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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